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The impact is particularly pronounced in industries that emphasize physical appearance, such as customer-facing roles.[63] Individuals with obesity may be passed over for positions, excluded from leadership pipelines, or denied training opportunities

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56 As the disease progresses, defects in fatty acid oxidation due to the repression of transcription factors, such as sterol regulatory element-binding proteins and peroxisome proliferator-activated receptor-, result in energy depletion and the release of mitochondrial RNA/DNA, activating inflammatory pathways involving interferon regulatory transcription factor and transforming growth factor-beta (TGF-)

Most people think of reflux as a simple chemical burn, but it is actually a source of oxidative stress